diff --git a/soc/st/stm32/stm32u0x/Kconfig.defconfig b/soc/st/stm32/stm32u0x/Kconfig.defconfig
index ead7304473e..0b947794cb3 100644
--- a/soc/st/stm32/stm32u0x/Kconfig.defconfig
+++ b/soc/st/stm32/stm32u0x/Kconfig.defconfig
@@ -7,4 +7,13 @@ if SOC_SERIES_STM32U0X
 
 rsource "Kconfig.defconfig.stm32u0*"
 
+if I2C_STM32
+
+config SHARED_INTERRUPTS
+	default y if $(dt_nodelabel_enabled,i2c2) && $(dt_nodelabel_enabled,i2c3)
+	default y if $(dt_nodelabel_enabled,i2c2) && $(dt_nodelabel_enabled,i2c4)
+	default y if $(dt_nodelabel_enabled,i2c3) && $(dt_nodelabel_enabled,i2c4)
+
+endif # I2C_STM32
+
 endif # SOC_SERIES_STM32U0X