diff --git a/boot/zephyr/boards/thingy53_nrf5340_cpuapp.conf b/boot/zephyr/boards/thingy53_nrf5340_cpuapp.conf
new file mode 100644
index 00000000..5398c638
--- /dev/null
+++ b/boot/zephyr/boards/thingy53_nrf5340_cpuapp.conf
@@ -0,0 +1,66 @@
+CONFIG_SIZE_OPTIMIZATIONS=y
+
+CONFIG_SYSTEM_CLOCK_DISABLE=y
+CONFIG_SYSTEM_CLOCK_NO_WAIT=y
+CONFIG_PM=n
+
+CONFIG_MAIN_STACK_SIZE=10240
+CONFIG_MBEDTLS_CFG_FILE="mcuboot-mbedtls-cfg.h"
+
+CONFIG_BOOT_UPGRADE_ONLY=y
+CONFIG_BOOT_MAX_IMG_SECTORS=2048
+CONFIG_BOOT_SIGNATURE_TYPE_RSA=y
+
+# Flash
+CONFIG_FLASH=y
+CONFIG_BOOT_ERASE_PROGRESSIVELY=y
+CONFIG_SOC_FLASH_NRF_EMULATE_ONE_BYTE_WRITE_ACCESS=y
+CONFIG_FPROTECT=n
+
+# Serial
+CONFIG_SERIAL=y
+CONFIG_UART_LINE_CTRL=y
+
+# MCUBoot serial
+CONFIG_GPIO=y
+CONFIG_MCUBOOT_SERIAL=y
+CONFIG_BOOT_SERIAL_CDC_ACM=y
+CONFIG_BOOT_SERIAL_DETECT_PORT="GPIO_1"
+CONFIG_BOOT_SERIAL_DETECT_PIN=13
+
+# Required by QSPI
+CONFIG_NORDIC_QSPI_NOR=y
+CONFIG_NORDIC_QSPI_NOR_FLASH_LAYOUT_PAGE_SIZE=4096
+CONFIG_NORDIC_QSPI_NOR_STACK_WRITE_BUFFER_SIZE=16
+
+CONFIG_PM_EXTERNAL_FLASH=y
+CONFIG_PM_EXTERNAL_FLASH_DEV_NAME="MX25R64"
+CONFIG_PM_EXTERNAL_FLASH_BASE=0x0
+CONFIG_PM_EXTERNAL_FLASH_SIZE=0x800000
+
+# Required by USB and QSPI
+CONFIG_MULTITHREADING=y
+
+# USB
+CONFIG_USB=y
+CONFIG_USB_DEVICE_MANUFACTURER="Nordic Semiconductor ASA"
+CONFIG_USB_DEVICE_PRODUCT="Bootloader Thingy:53"
+CONFIG_USB_DEVICE_VID=0x1915
+CONFIG_USB_DEVICE_PID=0x5300
+CONFIG_USB_CDC_ACM=y
+
+# Decrease memory footprint
+CONFIG_CBPRINTF_NANO=y
+CONFIG_TIMESLICING=n
+CONFIG_BOOT_BANNER=n
+CONFIG_CONSOLE=n
+CONFIG_CONSOLE_HANDLER=n
+CONFIG_UART_CONSOLE=n
+CONFIG_USE_SEGGER_RTT=n
+CONFIG_LOG=n
+CONFIG_ERRNO=n
+CONFIG_PRINTK=n
+CONFIG_RESET_ON_FATAL_ERROR=n
+CONFIG_SPI=n
+CONFIG_I2C=n
+CONFIG_UART_NRFX=n