diff --git a/net/sixlowpan/sixlowpan_hc06.c b/net/sixlowpan/sixlowpan_hc06.c
index 5fb1e81709..ebf7a318e2 100644
--- a/net/sixlowpan/sixlowpan_hc06.c
+++ b/net/sixlowpan/sixlowpan_hc06.c
@@ -499,9 +499,15 @@ static void uncompress_addr(FAR const struct netdev_varaddr_s *addr,
 
       for (i = destndx; i < endndx; i++)
         {
-          /* Big-endian, network order */
+#ifdef CONFIG_BIG_ENDIAN
+          /* Preserve big-endian, network order */
 
           ipaddr[i] = (uint16_t)srcptr[0] << 8 | (uint16_t)srcptr[1];
+#else
+          /* Preserve big-endian, network order */
+
+          ipaddr[i] = (uint16_t)srcptr[1] << 8 | (uint16_t)srcptr[0];
+#endif
           srcptr += 2;
         }